en <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Aims:</span></span></span></b><span style="font-size:10.0pt"><span cambria="" style="font-family:"> Despite the urgent need to treat the COVID-19 pandemic, no effective treatment has been identified to date. The present study aimed to compare the effects of interferon Beta-1 and dexamethasone on the treatment of hospitalized COVID-19 patients.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Materials & Methods:</span></span></span></b> <span style="font-size:10.0pt"><span cambria="" style="font-family:">This phase 2, open-label, randomized trial examined adult patients who were admitted to hospitals in Yasuj, Iran, from October 2021 to May 2022 due to COVID-19. Patients were randomly assigned to intervention group 1 (88 patients), which included remdesivir, interferon beta-1, and dexamethasone, and intervention group 2 (88 patients), which included remdesivir and dexamethasone, in a ratio of 1:1. The mean arterial blood O₂ saturation and length of hospitalization for both groups were compared.</span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:normal"><span 2="" lancet="" shaker="" style="font-family:"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Findings:</span></span></span></b> <span style="font-size:10.0pt"><span cambria="" style="font-family:">The two groups did not show a significant difference in terms of demographic characteristics and disease-related parameters at baseline (p>0.05). The mean O₂ saturation at the time of discharge for group 1 (90.14&plusmn;10.72) and group 2 (92.54&plusmn;3.19) demonstrated a significant difference (p<0.05). The mean length of hospitalization for group 1 (7.02&plusmn;2.56) and group 2 (5.73&plusmn;2.04) was significantly different (p<0.01). There was a significant difference between the number of deaths in group 1 (7 patients) and group 2 (0 patients; p<0.01).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span style="font-size:10.0pt"><span cambria="" style="font-family:"><span style="color:#44546a">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span cambria="" style="font-family:">The administration of remdesivir and dexamethasone, compared to remdesivir, dexamethasone, and interferon, results in a decreased length of hospitalization, reduced mortality, and improved O₂ saturation.</span></span></span></span></span></span> Patients,Interferons,Dexamethasone,COVID-19, 97 103 http://jccs.daneshafarand.org/browse.php?a_code=A-10-346-2&slc_lang=en&sid=8 M.A. Fazeli 1003194753284600387740 1003194753284600387740 No Department of Infectious Disease, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran M. Malekzadeh 1003194753284600387741 1003194753284600387741 No Social Determinant of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran H. Bayatmanesh 1003194753284600387739 1003194753284600387739 No “Imam Sajad Hospital” and “Department of Nursing, Faculty of Nursing & Midwifery”, Yasuj University of Medical Sciences, Yasuj, Iran P. Neysarian 1003194753284600387738 1003194753284600387738 No “Shahid Jalil Hospital” and “Department of Midwifery, Faculty of Nursing & Midwifery”, Yasuj University of Medical Sciences, Yasuj, Iran N. Arefkhah 1003194753284600387717 1003194753284600387717 No Department of Infectious Disease, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran M. Sedaghattalab 1003194753284600387716 1003194753284600387716 Yes Department of Internal Medicine, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran