en <strong>Aims<em>:</em></strong> With the announcement of the coronavirus pandemic by the World Health Organization, many people experienced many waves of panic. The disease was a major threat to individuals&#39; physical and mental health because of the rapid spread and severe mortality. The continued development and changes in the educational process can affect student&#39;s mental health. This study aimed to investigate the frequency of posttraumatic stress disorder, anxiety, depression, and stress in students of Rafsanjan University of Medical Sciences during the coronavirus outbreak in 2020.<br> <strong>Materials & Methods:</strong> This cross-sectional descriptive study was conducted on students of Rafsanjan University of Medical Sciences. The sample size was 351 individuals selected by the convenience sampling method. Data were collected by DASS-21 and IES-R. Data were analyzed by SPSS18 using the chi-squared and Fisher&#39;s exact tests.<br> <strong>Findings:</strong> The majority of students had moderate anxiety (33.6%) and posttraumatic stress disorder (26.2%). Depression (38.5%) and stress (55.3%) were not common in most students. Analysis of logistic regression showed a significant correlation between anxiety, stress, depression, and Posttraumatic stress disorder (p<0.05).<br> <strong>Conclusion:</strong> The results suggest mental health problems among medical students. Therefore, it is recommended to implement psychological counseling programs to reduce these cases. COVID-19,Students,Anxiety,Depression,Stress,Posttraumatic stress disorder, 87 93 http://jccs.daneshafarand.org/browse.php?a_code=A-10-128-1&slc_lang=en&sid=8 A. Najjar Mohiabadi 1003194753284600387185 1003194753284600387185 No Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran M. Tajadini maryam.tajadiny@gmail.com 1003194753284600387186 1003194753284600387186 Yes Department of Anesthesiology, Faculty of Para‐ medical, Rafsanjan University of Medical Sci‐ ences, Rafsanjan, Iran S.H. Seyedbagheri 1003194753284600387184 1003194753284600387184 No “Non-Communicable Diseases Research Center” and “Department of Pediatric Nursing, Nursing and Midwifery School”, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y. Soltanmoradi 1003194753284600387183 1003194753284600387183 No Department of Operating Room, Faculty of Paramedical, Rafsanjan University of Medical Sciences, Rafsanjan, Iran A.R. Sayadi 1003194753284600387182 1003194753284600387182 No “Department of Psychiatric Nursing, School of Nursing and Midwifery” and “Social Deter‐ minants of Health Research Center”, Rafsanjan University of Medical Sciences, Rafsanjan, Iran F. Harandi 1003194753284600387180 1003194753284600387180 No Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran M. Jamali 1003194753284600387181 1003194753284600387181 No Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran M.H. Kamrani 1003194753284600387179 1003194753284600387179 No Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran H. Khodadadi 1003194753284600387178 1003194753284600387178 No “Non-Communicable Diseases Research Cen‐ ter” and “Department of Health in Disasters and Emergencies, School of Health”, Rafsanjan Uni‐ versity of Medical Sciences, Rafsanjan, Iran