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Volume 7, Issue 2 (2026)
3 2026, 7(2): 93-100 |
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Received: 2026/03/2 | Accepted: 2026/04/29 | Published: 2026/05/15
Received: 2026/03/2 | Accepted: 2026/04/29 | Published: 2026/05/15
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Yousif B. Effect of Low-Level Laser Therapy on Skin Wound Healing and Inflammatory Biomarkers. 3 2026; 7 (2) :93-100
URL: http://jccs.daneshafarand.org/article-8-87255-en.html
URL: http://jccs.daneshafarand.org/article-8-87255-en.html
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General Directorate of Education, Najaf, Iraq
Abstract (65 Views)
Aims: This trial evaluated whether low-level laser therapy (LLLT), also termed photobiomodulation, added to standard wound care improves skin wound healing, local perfusion, pain, and systemic inflammatory biomarkers in women with superficial or partial-thickness wounds.
Materials & Methods: In this prospective, parallel-group randomized controlled trial, 360 women aged 18–65 years were allocated 1:1 to standard wound care plus 660-nm diode laser irradiation (n=180; 100 mW, continuous wave, 4 J/cm² per point, three sessions weekly for four weeks) or standard care alone (n=180). The primary outcome was the percentage reduction in wound area at week 4, measured by standardized digital planimetry. Secondary outcomes were serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP), pain on a visual analog scale, peri-wound perfusion and temperature, complete healing, satisfaction, and adverse events. Groups were compared using t-tests, analysis of covariance, mixed-model analysis, and chi-square tests (α=0.05).
Findings: Mean percentage wound-area reduction at week 4 in each group, with between-group differences (95% CI) and p-values; changes in TNF-α, IL-6, CRP, pain, and perfusion; complete-healing rates and adverse events.
Conclusion: Adjunctive 660-nm LLLT accelerates wound closure, reduces inflammatory markers and is safe.
Materials & Methods: In this prospective, parallel-group randomized controlled trial, 360 women aged 18–65 years were allocated 1:1 to standard wound care plus 660-nm diode laser irradiation (n=180; 100 mW, continuous wave, 4 J/cm² per point, three sessions weekly for four weeks) or standard care alone (n=180). The primary outcome was the percentage reduction in wound area at week 4, measured by standardized digital planimetry. Secondary outcomes were serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP), pain on a visual analog scale, peri-wound perfusion and temperature, complete healing, satisfaction, and adverse events. Groups were compared using t-tests, analysis of covariance, mixed-model analysis, and chi-square tests (α=0.05).
Findings: Mean percentage wound-area reduction at week 4 in each group, with between-group differences (95% CI) and p-values; changes in TNF-α, IL-6, CRP, pain, and perfusion; complete-healing rates and adverse events.
Conclusion: Adjunctive 660-nm LLLT accelerates wound closure, reduces inflammatory markers and is safe.
Keywords:
Low-Level Laser Therapy [MeSH], Photobiomodulation [MeSH], Wound Healing [MeSH], TNF-α [MeSH], Interleukin-6 [MeSH], Inflammation [MeSH]
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